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KMID : 1188320140080050563
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Gut and Liver
2014 Volume.8 No. 5 p.563 ~ p.568
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Total Cholesterol Level for Assessing Pancreatic Insufficiency Due to Chronic Pancreatitis
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Kenji Hirano
Tomotaka Saito
Suguru Mizuno
Minoru Tada
Naoki Sasahira
Hiroyuki Isayama
Miho Matsukawa
Gyotane Umefune
Dai Akiyama
Kei Saito
Shuhei Kawahata
Naminatsu Takahara
Rie Uchino
Tsuyoshi Hamada
Koji Miyabayashi
Dai Mohri
Takashi Sasaki
Hirofumi Kogure
Natsuyo Yamamoto
Yosuke Nakai
Kazuhiko Koike
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Abstract
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Background/Aims:To determine the nutritional markers important for assessing the degree of pancreatic insufficiency due to chronic pancreatitis in routine clinical practice.
Methods:A total of 137 patients with chronic pancreatitis were followed up for more than 1 year. They were divided into two groups: a pancreatic diabetes mellitus (DM) group, consisting of 47 patients undergoing medical treatment for DM of pancreatic origin, and a nonpancreatic DM group, consisting of 90 other patients (including 86 patients without DM). Serum albumin, prealbumin, total cholesterol, cholinesterase, magnesium, and hemoglobin were compared between the two groups.
Results:The total cholesterol was significantly lower in the pancreatic than the nonpancreatic DM group (164 mg/dL vs 183 mg/dL, respectively; p=0.0028). Cholinesterase was significantly lower in the former group (263 U/L vs 291 U/L, respectively; p=0.016). Among the 37 patients with nonalcoholic pancreatitis, there was no difference in the cholinesterase levels between the pancreatic and nonpancreatic (296 U/L vs 304 U/L, respectively; p=0.752) DM groups, although cholesterol levels remained lower in the former (165 mg/dL vs 187 mg/dL, respectively; p=0.052).
Conclusions:Cholinesterase levels are possibly affected by concomitant alcoholic liver injury. The total cholesterol level should be considered when assessing pancreatic insufficiency due to chronic pancreatitis.
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KEYWORD
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Chronic pancreatitis, Pancreatic exocrine insufficiency, Diabetes mellitus, Cholesterol, Cholinesterase
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